Andrew Spence was born in 1947 and lives and works in New York. He attended University of California, Santa Barbara, and Tyler School of Art at Temple University.

Spence has been represented by Edward Thorp Gallery, Max Protetch Gallery, and Barbara Toll Fine Arts, and has been in numerous group exhibitions including at the Metropolitan Museum of Art, New Acquisitions/Whitney Museum of American Art, Corcoran Gallery of Art, Hirshhorn Museum & Sculpture Garden ,Lisson Gallery, London, 1989 Whitney Biennial, Center for Fine Art, Miami, American Academy of Arts and Letters, New York; and New York Studio School.