Isca Greenfield-Sanders lives and works in New York City. In 2000, she received a B.A. in math and a B.A. in visual arts from Brown University and in 2001 she was a visiting artist at the American Academy in Rome.

Greenfield-Sanders has had solo exhibitions at Haunch of Venison, New York and London,  John Berggruen Gallery, San Francisco, Galerie Klüser, Munich, Baldwin Gallery, Aspen, Goff + Rosenthal, New York, Lombard Freid Fine Arts, New York, and Galeria In Arco, Torino.  In 2010 her work was the subject of a solo exhibition titled "Light Leaks" at the Museum of Contemporary Art Denver.  Her work was the subject of a two-person exhibition at the Museum Morsbroich in Leverkusen, Germany in 2006 and in 2003 she created a project room at P.S. 1 Contemporary Art Center. Her work is in public collections including the Solomon R. Guggenheim Museum in New York, The Museum of Fine Arts, Houston, The Museum Morsbroich in Leverkusen and the Progressive Collection in Ohio.